Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds

Platonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition biological activities of bacuri’s shell seeds extracts, considered residues from consumption industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, volkensiflavone) were identified extracts by high-performance liquid chromatography-diode array detection (HPLC-DAD), chromatography tandem mass spectrometry (LC-MS/MS), chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) techniques. Morelloflavone was main compound ethyl acetate extract, being responsible high vitro (50% effective concentration (EC50) ranging 8.0-10.5 µg mL−1 different protocols), anti-glycant (80%), moderate inhibition nitric oxide (1.56 > 90% cell viability) activities. This extract showed promising vivo activity evaluated through paw edema protocol after incorporation into a liquid-crystalline drug carrier system, reducing up to 31%. The results demonstrated potential fruit development drugs natural origin corroborated add economic value these discarded residues.